Purpose Detection and prediction of the rate of brain volume loss with age is a significant unmet need in patients with primary progressive multiple sclerosis (PPMS). In this study we construct detailed brain volume maps for PPMS patients. These maps compare age-related changes in both cortical and sub-cortical regions with those in healthy individuals. Methods We conducted retrospective analyses of brain volume using T1-weighted Magnetic Resonance Imaging (MRI) scans of a large cohort of PPMS patients and healthy subjects. The volume of brain parenchyma (BP), cortex, white matter (WM), deep gray matter, thalamus, and cerebellum were measured using the robust SynthSeg segmentation tool. Age- and gender-related regression curves were constructed based on data from healthy subjects, with the 95% prediction interval adopted as the normality threshold for each brain region. Results We analyzed 495 MRI scans from 169 PPMS patients, aged 20-79 years, alongside 563 exams from healthy subjects aged 20-86. Compared to healthy subjects, a higher proportion of PPMS patients showed lower than expected brain volumes in all regions except the cerebellum. The most affected areas were BP, WM, and thalamus. Lower brain volumes correlated with longer disease duration for BP and WM, and higher disability for BP, WM, cortex, and thalamus. Conclusions Constructing age- and gender-related brain volume maps enabled identifying PPMS patients at a higher risk of brain volume loss. Monitoring these high-risk patients may lead to better treatment decisions and improve patient outcomes.
Detection and prediction of brain-volume loss with age is a significant unmet need in primary-progressive multiple sclerosis (PPMS).
2.Contribution
Detailed cortical and sub-cortical brain-volume maps for PPMS patients versus healthy norms.
Analysis of 495 MRI scans from 169 PPMS patients using robust SynthSeg segmentation.
3.Architecture, methodology & evidence status
Evidence & statusThis is a peer-reviewed journal article published in Neuroradiology (2024). The full text and record of version are held by the publisher; this page is an archival record with a link to the official version.
The abstract above is the authoritative summary of the work as posted at the official source. This archival record does not add results, figures or claims beyond those in the published/posted manuscript. For the complete methodology, results and references, consult the official record.
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Warszawer, Y., Gurevich, M., Kerpel, A., Alster, S. D., Nissan, Y., Shirbint, E., Hoffmann, C., & Achiron, A. (2024). Mapping brain volume change across time in primary-progressive multiple sclerosis. Neuroradiology. https://doi.org/10.1007/s00234-024-03354-7
Yehuda Warszawer, Michael Gurevich, Ariel Kerpel, Sapir Dreyer Alster, Yael Nissan, Emanuel Shirbint, Chen Hoffmann, and Anat Achiron. 2024. “Mapping brain volume change across time in primary-progressive multiple sclerosis.” Neuroradiology. https://doi.org/10.1007/s00234-024-03354-7.
@article{shirbint2024ppmsbrainvolume,
title = {Mapping brain volume change across time in primary-progressive multiple sclerosis},
author = {Yehuda Warszawer and Michael Gurevich and Ariel Kerpel and Sapir Dreyer Alster and Yael Nissan and Emanuel Shirbint and Chen Hoffmann and Anat Achiron},
year = {2024},
doi = {10.1007/s00234-024-03354-7},
url = {https://doi.org/10.1007/s00234-024-03354-7},
note = {Peer-reviewed journal article}
}
TY - JOUR
AU - Yehuda Warszawer
AU - Michael Gurevich
AU - Ariel Kerpel
AU - Sapir Dreyer Alster
AU - Yael Nissan
AU - Emanuel Shirbint
AU - Chen Hoffmann
AU - Anat Achiron
TI - Mapping brain volume change across time in primary-progressive multiple sclerosis
PY - 2024
DO - 10.1007/s00234-024-03354-7
UR - https://doi.org/10.1007/s00234-024-03354-7
N1 - Peer-reviewed journal article
ER -