Clinical AI and Multiple Sclerosis Research

Research questions

• What is the safety and humoral efficacy of COVID-19 vaccination in people with multiple sclerosis?
• How does brain volume change across time in primary-progressive MS relative to healthy norms?
• How can spinal structures and finger dexterity be measured robustly for clinical use?

Constituent works

1. PreprintEmpirical Study

   TotalSpineSeg: Robust Spine Segmentation with Landmark-Based Labeling in MRI

   Yehuda Warszawer, Nathan Molinier, Jan Valošek, Pierre-Louis Benveniste, Sandrine Bédard, Emanuel Shirbint, Feroze B. Mohamed, Charidimos Tsagkas, Shannon Kolind, Larry Lynd, Jiwon Oh, Alexandre Prat, Roger Tam, Anthony Traboulsee, Scott Patten, Lisa Eunyoung Lee, Anat Achiron, Julien Cohen-Adad

   2025 · ResearchGate (preprint) · associated conference material · doi:10.13140/RG.2.2.31318.56649 · Preprint; associated conference work is not a journal peer-review record

   Accurate segmentation and labeling of spinal structures are essential for diagnosing and managing spinal pathologies. TotalSpineSeg uses cascaded nnU-Net models and landmark-guided iterative labeling to segment vertebrae, intervertebral discs, spinal cord, and spinal canal across MRI contrasts.

   Read recordDOI

2. Peer ReviewedEmpirical Study

   Development of an interactive biosensing application for assessing finger dexterity

   Michal Greenberg Abrahami, Yehuda Warszawer, Alon Kalron, Emanuel Shirbint, Maria Didikin, Anat Achiron

   2025 · Digital Health · doi:10.1177/20552076241297734 · Peer-reviewed journal article

   Objective Accurate finger function assessment is crucial for monitoring the performance of daily hand activities. However, specialized digital applications are lacking for evaluating various finger tasks. This study aims to develop a custom digital biosensing application to assess finger dexterity.…

   Read recordDOI

3. Peer ReviewedEmpirical Study

   Mapping brain volume change across time in primary-progressive multiple sclerosis

   Yehuda Warszawer, Michael Gurevich, Ariel Kerpel, Sapir Dreyer Alster, Yael Nissan, Emanuel Shirbint, Chen Hoffmann, Anat Achiron

   2024 · Neuroradiology · doi:10.1007/s00234-024-03354-7 · Peer-reviewed journal article

   Purpose Detection and prediction of the rate of brain volume loss with age is a significant unmet need in patients with primary progressive multiple sclerosis (PPMS). In this study we construct detailed brain volume maps for PPMS patients. These maps compare age-related changes in both cortical and…

   Read recordDOI

4. Peer ReviewedEmpirical Study

   COVID-19 vaccination in patients with multiple sclerosis: Safety and humoral efficacy of the third booster dose

   Sapir Dreyer-Alster, Shay Menascu, Mathilda Mandel, Emanuel Shirbint, David Magalashvili, Mark Dolev, Shlomo Flechter, Uri Givon, Diana Guber, Yael Stern, Shmuel Miron, Michael Polliack, Rina Falb, Polina Sonis, Michael Gurevich, Anat Achiron

   2022 · Journal of the Neurological Sciences · doi:10.1016/j.jns.2022.120155 · Peer-reviewed journal article

   Background As immunity against SARS-COV-2 wanes following first and second doses of vaccination, a third dose is administered in several countries around the world. Similarly to the first doses, risks related to vaccination and humoral immune response in patients with multiple sclerosis (MS) need…

   Read recordDOI

5. Peer ReviewedEmpirical Study

   COVID-19 vaccination in patients with multiple sclerosis: What we have learnt by February 2021

   Anat Achiron, Mark Dolev, Shay Menascu, Daniela-Noa Zohar, Sapir Dreyer-Alster, Shmuel Miron, Emanuel Shirbint, David Magalashvili, Shlomo Flechter, Uri Givon, Diana Guber, Yael Stern, Michael Polliack, Rina Falb, Michael Gurevich

   2021 · Multiple Sclerosis Journal · doi:10.1177/13524585211003476 · Peer-reviewed journal article

   Background Since vaccination against coronavirus disease 2019 (COVID-19) became available, risks related to vaccinating patients with multiple sclerosis (MS) need to be carefully assessed. Objective Characterize safety and occurrence of immediate relapses following COVID-19 vaccination in a large…

   Read recordDOI

Evidence status & planned validation

Four peer-reviewed journal articles and one preprint with associated code and conference material.

Manuscripts in this series build on a shared architecture; the abstracts and records above state each work's independent status.

← All research series · Complete archive