Research Area
Clinical AI
Peer-reviewed clinical research and applied data/imaging methods in multiple sclerosis — vaccination safety and immune response, brain-volume mapping, spine segmentation, and digital assessment of function.
Works in this area (6)
-
PreprintConceptual Framework
From Plausible Narrative to Sound Abduction: A Governed Abductive Architecture for Medical Digital Twins in Multiple Sclerosis Care
Large language models (LLMs) embedded in medical Patient Digital Twins (PDTs) exhibit a systemic vulnerability: they can generate fluent, narratively persuasive, yet abductively unsound clinical explanations. In this context, abductive soundness means that an explanation preserves mechanistic…
-
PreprintEmpirical Study
TotalSpineSeg: Robust Spine Segmentation with Landmark-Based Labeling in MRI
Accurate segmentation and labeling of spinal structures are essential for diagnosing and managing spinal pathologies. TotalSpineSeg uses cascaded nnU-Net models and landmark-guided iterative labeling to segment vertebrae, intervertebral discs, spinal cord, and spinal canal across MRI contrasts.
-
Peer ReviewedEmpirical Study
Development of an interactive biosensing application for assessing finger dexterity
Objective Accurate finger function assessment is crucial for monitoring the performance of daily hand activities. However, specialized digital applications are lacking for evaluating various finger tasks. This study aims to develop a custom digital biosensing application to assess finger dexterity.…
-
Peer ReviewedEmpirical Study
Mapping brain volume change across time in primary-progressive multiple sclerosis
Purpose Detection and prediction of the rate of brain volume loss with age is a significant unmet need in patients with primary progressive multiple sclerosis (PPMS). In this study we construct detailed brain volume maps for PPMS patients. These maps compare age-related changes in both cortical and…
-
Peer ReviewedEmpirical Study
COVID-19 vaccination in patients with multiple sclerosis: Safety and humoral efficacy of the third booster dose
Background As immunity against SARS-COV-2 wanes following first and second doses of vaccination, a third dose is administered in several countries around the world. Similarly to the first doses, risks related to vaccination and humoral immune response in patients with multiple sclerosis (MS) need…
-
Peer ReviewedEmpirical Study
COVID-19 vaccination in patients with multiple sclerosis: What we have learnt by February 2021
Background Since vaccination against coronavirus disease 2019 (COVID-19) became available, risks related to vaccinating patients with multiple sclerosis (MS) need to be carefully assessed. Objective Characterize safety and occurrence of immediate relapses following COVID-19 vaccination in a large…